Backup Exec and the Exchange database logfiles
Image this: You’ve setup a new machine, running Exchange 2003, installed Backup Exec with AOFO, and start running your backups. Everything works fine.
A few days later, the clients calls you, telling you that Exchange is no longer working. You connect to the machine through VPN, and see that the log partition (you do have log partition, don’t you?) ran full. But you have properly set up your backups and everything. But the log files don’t get deleted.
When using Backup Exec with the Advanced Open File Option (AOFO, Snapshots), BE might not delete the backed up exchange database logfiles.
The culprit here is the option “Process logical volumes for backup one at a time” option.
When you activate this option, BE will no longer delete your Exchange logfiles. I do not really understand why this is the case, but i was able to get it to work fine without this option, by shutting down some services in preparation to preparing the snapshots.

Mike Furgerson:
I have been told by Symantec that we should not use AOFO on exchange backups. Can’t remember why.
25. March, 2008, 14:44EXCH - Hilfe - Translogs werden nicht gelöscht - MCSEboard.de MCSE Forum:
[...] dieses Problem Backup Exec and the Exchange database logfiles Lukas Beeler’s IT Blog Blog Archive Kurzform: Wenn du "Process logical volumes for backup one at a time" aktiviert hast [...]
7. October, 2008, 10:00